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Mohammad Nuril Amin, M.D.
Faculty Appointment: Research Assistant Professor, Department of Internal Medicine
Specialty: Rheumatology
Research Interests: I have been elucidating the role of angiogenesis in RA since I joined Dr. Alisa Koch's laboratory. I have interesting data suggesting that there is impaired angiogenesis in female P-selectin gene deficient mice compared to female wild type mice. I will elucidate the mechanisms involved in impaired angiogenesis in female P-selectin gene deficient mice and its clinical significance in relation to estrogen receptor using hormone responsive tumors in SCID mice. I will also explore the clinical significance of this finding in animal models of RA. I will expand this finding to determine the pathogenesis and mechanisms of why females have a greater incidence of many rheumatic diseases such as RA. In another project, I have found that fucosyltransferase 1 (Fut 1), a gene involved in the final step in the synthesis of the 4A11 antigen, is cytokine-inducible in ECs and RA ST fibroblasts. Fut 1 plays an essential role in angiogenesis, as suggested by impaired angiogenesis in various animal models of angiogenesis using Fut 1 null mice. In the future, my goal will be to elucidate the mechanisms involved in decreased angiogenesis in Fut 1 null mice. I will also use silencing interfering RNA as well as sense and antisense oligodeoxynucleotides directed against Fut 1 to determine the role of Fut 1 in angiogenesis. I have obtained unique data suggesting that Fut 1 null mice are resistant to development of an animal model of arthritis. I will examine the role of Fut 1 in animal models of RA and the signaling mechanisms involved in decreased arthritis in Fut 1 null mice.
Degree: M.D., 1987, Allama Iqbal Medical College
Fellowships: Postdoctoral Research Fellowship, Rheumatology, 2003, Northwestern University
Postdoctoral Research Fellowship, Rheumatology, 2005, University of Michigan
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