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Mohammad Nuril Amin, M.D.
 
Faculty Appointment: Research Assistant Professor, Department of Internal Medicine
Specialty: Rheumatology
Rheumatology
Research Interests: I have been elucidating the role of angiogenesis in RA since I joined Dr. Alisa Koch's laboratory. I have interesting data suggesting that there is impaired angiogenesis in female P-selectin gene deficient mice compared to female wild type mice. I will elucidate the mechanisms involved in impaired angiogenesis in female P-selectin gene deficient mice and its clinical significance in relation to estrogen receptor using hormone responsive tumors in SCID mice. I will also explore the clinical significance of this finding in animal models of RA. I will expand this finding to determine the pathogenesis and mechanisms of why females have a greater incidence of many rheumatic diseases such as RA. In another project, I have found that fucosyltransferase 1 (Fut 1), a gene involved in the final step in the synthesis of the 4A11 antigen, is cytokine-inducible in ECs and RA ST fibroblasts. Fut 1 plays an essential role in angiogenesis, as suggested by impaired angiogenesis in various animal models of angiogenesis using Fut 1 null mice. In the future, my goal will be to elucidate the mechanisms involved in decreased angiogenesis in Fut 1 null mice. I will also use silencing interfering RNA as well as sense and antisense oligodeoxynucleotides directed against Fut 1 to determine the role of Fut 1 in angiogenesis. I have obtained unique data suggesting that Fut 1 null mice are resistant to development of an animal model of arthritis. I will examine the role of Fut 1 in animal models of RA and the signaling mechanisms involved in decreased arthritis in Fut 1 null mice.
Degree: M.D., 1987, Allama Iqbal Medical College
Fellowships: Postdoctoral Research Fellowship, Rheumatology, 2003, Northwestern University
Postdoctoral Research Fellowship, Rheumatology, 2005, University of Michigan
Academic office address Biomedical Science Research Building
109 Zina Pitcher Place
Room 4380
Ann Arbor, MI 48109-2200
Academic office telephone: (734)647-6383
Academic office FAX: (734)615-2506

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