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Our Faculty
Blake J Roessler, M.D.
 
Faculty Appointment: Professor, Department of Internal Medicine
Additional Titles: Director, Human Applications Laboratory
Director, Vector Core
Associate Director for Research Innovation, Michigan Institute for Clinical and Health Research
Specialty: Rheumatology
Clinical Interests: Experimental gene therapy.
Research Interests: Dr. Roessler has a broad-based research program that is exploring many facets of chondrocyte biology. One research project focuses on defining the patterns of gene expression in articular chondrocytes as a function of age and articular injury. The goal of this project is to identify molecular mechanisms associated with early osteoarthritis that may be targets for drug discovery. The project will also attempt to identify OA susceptibility gene candidates in canine pedigrees with a high incidence of spontaneous OA. In a correlate study Dr. Roessler and collaborators are exploring the use of Raman spectroscopy to identify early structural changes in extracellular matrix components of cartilage that may function as OA biomarkers. A second project is exploring the role of intra-articular adipocytes (fat cells) on chondrocyte biology and extracellular matrix structure. Dr. Roessler also has a long-standing interest in development of model systems and clinical applications of gene therapy, and is currently studying mechanisms of vector-host cell interactions.
Degree: M.D., 1983, University of Cincinnati
Certifications: 1986, Internal Medicine
2002, Rheumatology
Faculty Appointment Date: 11/1/1990
Academic office address Medical Science Research Building II
1150 West Medical Center Drive
Room 3560
Ann Arbor, MI 48109-5688
Academic office telephone: (734)763-7949
Academic office FAX: (734)764-3596
 
 
   
   

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