Matthias Kretzler, M.D.
Faculty Appointment:
Additional Title:	Research Professor, Computational Medicine and Biology
Specialty:	Nephrology
Clinical Interests:	The main focus of my clinical interest is on the diagnosis and management of glomerular diseases with a special emphasis on the evolving therapeutic strategies for renal autoimmune disease. In addition, the care for patients after renal transplantation to maintain optimal transplant function has been a major focus of my clinical work. Finally, the care for tuberous sclerosis patients with renal involvment and the emerging therpeutic options for this complex disorder have received my attention recently.
Research Interests:	The major research focus of my laboratory is on the use of modern molecular biology tools to better understand disease mechanism activated in human renal biopsies. We currently evaluate these novel tools for molecular diagnosis of kidney and transplant failure in international multicenter studies. The longstanding interest in my group has been on glomerular filtration barrier failure. Using cell and molecular biology approaches we have identified novel cell-matrix signaling molecules activated in glomerular failure. Intervening with their function might evolve into a novel therapeutic strategy and we are currently evaluate this approach with small molecule inhibitors in vitro and in vivo and in cell type specific knock out mice.
Degree:	M.D., 1992, University of Heidelberg
Professional Organizational Fellowships:	ASN, American Society of Nephrologists GSN, German Society of Nephrology EKRA, European Kidney Research Association AHA, American Heart Association NKF, National Kidney Foundation ANZSN, Australian-New Zealand Socitey of Nephrology
Residency:	1994-1999, Medizinische Poliklinik, University of Munich
Fellowships:	Physiology And Nephrology, 1994, University of Michigan Nephrology, 2002, University of Munich
Certifications:	2001, Internal Medicine (Germany) 2002, Nephrology (Germany)
Faculty Appointment Date:	11/1/2005
Academic office address	Medical Science Research Building II 1150 West Medical Center Drive Room 1560 Ann Arbor, MI 48109-5676
Academic office telephone:	(734)615-5757
Academic office FAX:	(734)763-0982
E-mail Address:	kretzler@umich.edu
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