Mariana Julieta Kaplan, M.D.
Faculty Appointment:	Associate Professor, Department of Internal Medicine
Specialty:	Rheumatology
Clinical Interests:	Systemic Lupus Erythematosus, Rheumatoid arthritis
Research Interests:	Dr. Kaplan's laboratory is investigating the pathophysiology of premature atherosclerosis in patients with SLE. Dr. Kaplan has identified mechanisms that induce apoptosis in vascular endothelial cells, and is studying activation of these mechanisms in SLE. Pro-apoptotic signaling correlates with abnormal endothelial cell function, promotion of atherosclerosis, and tissue factor generation. Her lab is also investigating whether the regenerative capacities of the endothelium are impaired in patients with SLE and other autoimmune diseases (rheumatoid arthritis and scleroderma) ,and whether this further contributes to premature vascular disease. Dr. Kaplan is also studying the phenotype and function of specific cell subsets in lupus, including myeloid dendritic cells and neutrophils, and whether abnormalities in these cells promote abnormal autoimmune responses. In addition, Dr. Kaplan's laboratory is looking into mechanisms of tissue damage in SLE and whether specific pharmacologic interventions can abrogate/ameliorate these complications in lupus and, potentially , in other autoimmune diseases.
Degree:	M.D., 1992, National Autonomous University of Mexico
Residency:	1992-1995, NIH
Fellowship:	Rheumatology, 1998, University of Michigan
Faculty Appointment Date:	7/1/1995
Academic office address	Medical Science Research Building I 1150 West Medical Center Drive Room 5520 Ann Arbor, MI 48109-5680
Academic office telephone:	(734)936-7905
Academic office FAX:	(734)763-4151
Lab