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Faculty Appointment:
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Professor,
Department of Orthopaedic Surgery
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Additional Titles: |
Associate Chair for Research, Department of Orthopaedic Surgery
Henry Ruppenthal Family Professor of Orthopaedic Surgery and Bioengineering
Professor, Department of Orthopaedic Surgery
Professor, Department of Mechanical Engineering
Research Professor, Institute of Gerontology
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| Specialty: |
Orthopedic Surgery
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| Research Interests: |
Dr. Goldstein's work ranges from studies on embryological bone formation to investigating the consequences of aging on bone integrity and responsiveness. From a clinical perspective, the work relates to genetic disorders of bone, such as osteogenesis imperfecta, to aging fragility, such as in osteoporosis. Substantial efforts are also dedicated to the study of augmenting bone repair or regeneration using tissue engineering strategies. Specifically, the research is focused on the study of mechanical and biologic regulators of bone formation, regeneration, and adaptation. Using a hierarchical approach, the laboratory tests hypotheses across multiple scales, ranging from signaling pathways associated with mechanotransduction to biomechanical material property characterizations. These studies have lead to the development of numerous devices to treat orthopaedic conditions, including surgical instruments and artificial joint components. Along with several colleagues, the laboratory has developed a method of delivering genes to wound sites, promoting "in situ tissue engineering" to treat bone defects, skin ulcers, and ischemic heart disease. In addition to investigating the potential of localized gene therapy for wound repair, Dr. Goldstein is also studying cell/matrix interactions and how physical forces can augment these relationships. The research program includes numerous collaborations with faculty from many different departments within the School of Medicine, School of Dentistry, the College of Literature, Science, and the Arts, and the College of Engineering. |
Education and Credentialing: |
| Degree: |
Ph.D., 1981, University of Michigan
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