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Mark Day , Ph.D.


 
Faculty Appointment: Professor, Department of Urology
Research Interests: Our research focuses on epithelial homeostasis of the prostate and mammary gland, which is critically dependent on steroid hormones. Alterations in the levels of theses hormones or to signaling pathways meditated by their receptors results in apoptotic cell death, tissue involution and remodeling. Although well studied, the precise mechanisms that mediate these changes remain vague. We have determined that a potential target of hormone action during involution may be the intercellular junction of adjacent secretory epithelium. This is supported by the long standing observation that one of the first visible stages of prostate and mammary involution is the disruption of interepithelial adhesion prior to the onset of apoptosis.

Education and Credentialing:
Degree: Ph.D., 1991, Washington University