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Faculty Appointment:
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Professor,
Department of Internal Medicine
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Additional Title: |
Associate Director of Research, Geriatric Research, Education and Clinical Center at VA Ann Arbor Healthcare System
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| Specialty: |
Geriatric Medicine, Rheumatology
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| Clinical Interests: |
Rheumatology, arthritis, immunology and geriatrics. |
| Research Interests: |
Dr. Yung's research focuses on understanding the relationship between immune senescence and the development of immune and inflammatory diseases in the elderly. Aging represents a state of low grade inflammation. Dr. Yung has shown that upregulation of T cell chemokine response occurs in aging animals and humans. The epigenetic `drift' that occurs with aging may be involved in the deregulation of the chemokine system in aging. Dr. Yung is also investigating the effect of aging on dendritic cell function. Using a murine melanoma cancer model, he showed that `old' dendritic cells (DCs) are much less effective than their younger cohort as an immunotherapeutic agent. This is linked to the impaired ability of DCs to ingest antigen and to stimulate T cells. These findings may help to explain why elderly patients are at risk for a multitude of immune/inflammatory diseases. |
Education and Credentialing: |
| Degree: |
M.B.,Ch.B., 1986, University of Liverpool, England
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| Residency: |
Sinai Hospital, 1988-1991, Detroit, Michigan, United States
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| Fellowships: |
Rheumatology,
1994, Univ of Michigan
Geriatric Medicine (Internal Medicine),
1996, Univ of Michigan
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| Certifications: |
1991,
Internal Medicine
1994,
Rheumatology
1998,
Geriatric Medicine
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| Language: |
Chinese |
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