| Evaluate for involvement: all limbs or lower limbs only? Bowel, bladder and/or sexual dysfunction? Incontinence? |
| If optic neurtitis, episodic weakness/sensory loss, consider multiple sclerosis or other demyelinating process |
| Myelopathy from spinal stenosis or degenerative process, extensive differential including CNS processes of brain and spine |
| Consider HIV risk |
| History of traumatic head injury, CVA |
| Family history of neurologic disorders |